Welcome to Powerplay


Self-employed since 1996 (as Power Play: Nutrition, Fitness, Performance) in the health and fitness industry. Registered Dietitian, Personal Trainer and an NSCA Certified Strength and Conditioning Specialist currently completing my PhD in “Nutritional Science, Genetics and Athletic Performance” at the University of Toronto. I specializes in advanced sports nutrition as an international consultant, and I’m  currently researching high performance athletes and their unique genetic response to dietary nutrients and supplements based on their genotype (DNA). My research will also look at associations of performance and body type to sport/muscle function genes in this athletic population.

*NEW* Sport-Nutrigenomix® test is NOW AVAILABLE. My goal is to help athletes (health/wellness test avail too) reach their genetic potential by aligning their diet and other performance-enhancements to their DNA. Details at www.nutrigenomix.com 

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What’s New

Nutrigenomix-Sport #Unleash Your Genetic Potential

My First Book! Honored to be the “Sport Nutrition Expert” in…

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What’s New

March 2018

Published PAP online Med Sci Sport Exerc (in press, August 2018) 



Caffeine, CYP1A2 genotype and endurance performance in athletes

Nanci Guest, Paul Corey, Jason Vescovi, and Ahmed El-Sohemy, University of Toronto 

Purpose: Many studies have examined the effect of caffeine on exercise performance, but findings have not always been consistent. The objective of this study was to determine whether variation in the CYP1A2 gene, which affects caffeine metabolism, modifies the ergogenic effects of caffeine in a 10-km cycling time trial. Methods: Competitive male athletes (n=101; age: 25 ± 4 years) completed the time trial under three conditions: 0, 2 or 4 mg of caffeine per kg body mass, using a split-plot randomized, double-blinded, placebo-controlled design. DNA was isolated from saliva and genotyped for the -163A>C polymorphism in the CYP1A2 gene (rs762551). Results: Overall, 4 mg/kg caffeine decreased cycling time by 3% (mean ± SEM) versus placebo (17.6 ± 0.1 vs. 18.1 ± 0.1 min, p = 0.01). However, a significant (p <0.0001) caffeine-gene interaction was observed. Among those with the AA genotype, cycling time decreased by 4.8% at 2 mg/kg (17.0 ± 0.3 vs. 17.8 ± 0.4 min, p = 0.0005) and by 6.8% at 4 mg/kg (16.6 ± 0.3 vs. 17.8 ± 0.4 min, p < .0001). In those with the CC genotype, 4 mg/kg increased cycling time by 13.7% versus placebo (20.8 ± 0.8 vs. 18.3 ± 0.5 min, p = 0.04). No effects were observed among those with the AC genotype. Conclusion: Our findings show that both 2 and 4 mg/kg caffeine improve 10-km cycling time, but only in those with the AA genotype. Caffeine had no effect in those with the AC genotype and diminished performance at 4 mg/kg in those with the CC genotype. CYP1A2 genotype should be considered when deciding whether an athlete should use caffeine for enhancing endurance performance.

Same Study: Poster from CNS January 2018 

Podcast March 1, 2016

Nutrigenomics and Athletic Performance with Sigma Nutrition


Poster presented at International Society of Sports Nutrition Annual Meeting June 2015, Austin, Texas

Title: Genetic variation related to caffeine metabolism or response during exercise

Outcome: Certain genotypes are associated with higher heart rate during exercise after caffeine ingestion

Nanci Guest_Caffeine and HR_Womack_Poster June 2015_FINAL_To_Print_June 9th


Nutrition • Training • Genetics

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